For about 30 minutes on Saturday afternoon, it looked like the Virginia Tech Hokies were about to win their second game in a row and move to 3-2 in ACC play. Unfortunately, a lopsided third quarter changed everything, and the No. 16 Louisville Cardinals (7-1, 4-1) came from behind to defeat the Hokies 28-16 (3-6, 2-3).

Isaac Brown rushed for 130 yards and a touchdown before leaving late with a leg injury and Keyjuan Brown scored twice in the second half to lift No. 16 Louisville to a 28-16 victory over Virginia Tech.

Louisville Cardinals running back Duke Watson (26) celebrates after scoring touchdown in the first half against EKU at the Cardinals' season opener Saturday, August 30, 2025 at L&N Federal Credit Union Stadium in Louisville, Kentucky. / Matt Stone/Courier Journal / USA TODAY NETWORK via Imagn Images

Who will miss the Louisville Cardinals' Week 10 ACC college football game vs. Virginia Tech? Here's the latest Louisville football injury report.

LOUISVILLE, Ky. (WDRB) — High school football is heating up all across the Louisville area. Sectional battles are underway in southern Indiana while Louisville-area teams are still grinding it out before playoffs begin. WDRB has all your Louisville-area high school football coverage, from scores and top-notch players to highlight-reel moments.

EA Sports released their first major ratings update for CFB26 since launch day, and several Cardinals had their overall rating impacted.

Louisville allowed Boston College to make this game much closer than it ever should have been. They started the fourth quarter with a clear opportunity to put the game away but it took until the two mintue warning to do so.